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2-胺基-5-(4-硝基苯磺酰)-噻唑的合成路線

提問時(shí)間:2021/4/26 17:08:04
2-胺基-5-(4-硝基苯磺酰)-噻唑是什么,有什么方法可以合成?

1條回復(fù):

匿名
2021/4/26 17:08:04
基本信息:
中文名稱 2-胺基-5-(4-硝基苯磺酰)-噻唑
中文別名 1-(4-氟芐基)-3-(4-異丁氧基芐基)-1-(1-甲基哌啶-4-基)脲;匹莫范色林;
英文名稱 Pimavanserin
英文別名 N-[(4-Fluorophenyl)Methyl]-N-(1-Methyl-4-piperidinyl)-N''-[[4-(2-Methylpropoxy)phenyl]Methyl]urea;N-(4-Fluorobenzyl)-N-(1-Methylpiperidin-4-yl)-N''-[[4-(2-Methylpropyloxy)phenyl]Methyl]carbaMide;N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N''-(4-(2-methylpropyloxy)phenylmethyl)carbamide;N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N''-(4-isobutoxybenzyl)carbamide;Unii-jz963p0dik;Pimavamserin;1-[(4-fluorophenyl)Methyl]-1-(1-Methylpiperidin-4-yl)-3-{[4-(2-Methylpropoxy)phenyl]Methyl}urea;1-(4-fluoro-benzyl)-3-(4-isobutoxy-benzyl)-1-(1-methyl-piperidin-4-yl)-urea;N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N''-(4-(2-methylpropyloxy)phenylmethyl) carbamide;PIMAVANSERIN/1-(4-FLUOROBENZYL)-3-(4-ISOBUTOXYBENZYL)-1-(1-METHYLPIPERIDIN-4-YL)UREA;
CAS號(hào) 706779-91-1

合成路線:
1.通過4-(異丁氧基)芐基異氰酸酯和N-(4-氟芐基)-1-甲基哌啶-4-胺合成2-胺基-5-(4-硝基苯磺酰)-噻唑,收率約59%;


中華試劑網(wǎng)提醒:合成路線僅供參考
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